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Plant sterol or stanol consumption does not affect ...

2006-2-15 · Tatematsu K, Fuma SY, Nagase T, Ichikawa Y, Fujii Y, Okuyama H (2004). Factors other than phytosterols in some vegetable oils affect the survival of SHRSP rats. Food Chem Toxicol 42, 1443–1451.

(PDF) Inherited Macrothrombocytopenias

Sitosterolemia (STSL, 210250) ... the GPIb-IX-V comple x on the plat ele t surfac e and, in combi- ... majorit y of patie nt s have mutat ions i n the typ ically deleted. chromosom al regi on.

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K JRA (STFP V.A 1988) predicted that the NWRA discharge may approach or exceed organoleptic criteria for 2,iI—dichlorophenel at all sites based on comparison of the analytical detection limit with a 50:1 dilution to the criteria of 0.3 ugh. This is a very conservative estimate since it is based on the detection limit concentration of the ...

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(PDF) A detailed Hapmap of the Sitosterolemia locus ...

Lu K, Lee MH, Yu H, Zhou Y, Sandell SA, Salen G, Patel SB: Molecu- lar cloning, genomi c organization, gene tic va riations, and characterization of …

Non-cholesterol sterols and cholesterol metabolism in ...

2013-10-10 · The role of PS in initiation of xanthomas and premature atherosclerosis is also discussed. Blocking sterols absorption with EZE has revolutionized STSL patient treatment as it reduces circulating levels of non-cholesterol sterols in STSL. However, none of the available treatments including EZE have normalized plasma PS concentrations.

Similar serum plant sterol responses of human subjects ...

2007-1-17 · Sugiuchi H, Uji Y, Okabe H, Irie T, Uekama K, Kayahara N et al. (1995). (1995). Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and ...

Plant sterol enriched functional food and atherosclerosis ...

2017-3-2 · However, Plat et al. ( 2014 ) found that the consumption of a diet enriched with oxyphytosterols, similar to the consumption of oxysterols, increased atherosclerotic lesions in LDL +/− mice. Also increased oxyphytosterol levels in patients with sitosterolaemia have led to speculations about potential pro-atherogenic effects of plant oxidation ...

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A detailed Hapmap of the Sitosterolemia locus spanning …

2006-2-28 · Sitosterolemia is an autosomal recessive disorder that maps to the sitosterolemia locus, STSL, on human chromosome 2p21. Two genes, ABCG5 and ABCG8, comprise the STSL and mutations in either cause sitosterolemia. ABCG5 and ABCG8 are thought to have evolved by gene duplication event and are arranged in a head-to-head configuration. We report here a …

Liver X receptor β (LXRβ): A link between β-sitosterol and ...

2008-2-12 · Administration of β-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male LXRβ−/− mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra. In mice at 5 months of age, β-sitosterol had no observed toxicity but at 16 months of age, it caused severe …

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Stanol esters decrease plasma cholesterol independently …

2004-12-1 · Dietary sterols derived from plants decrease plasma cholesterol levels (1, 2).Mechanisms for why plant sterols should do this have been debated (for review, see Ref. 3).Most evidence, however, points to an effect at the level of the intestine leading to a decrease in cholesterol absorption (4, 5, 6, 7) the lumen of the intestine, plant sterols compete with …

Non-cholesterol sterols and cholesterol metabolism in ...

2013-12-1 · 1. Introduction. Sitosterolemia (STSL) is a rare autosomal recessive lipid storage disease that is caused by homozygous or compound heterozygous mutations in either one of the two adenosine triphosphate binding cassette transporters genes, ABCG5>/8.These proteins are expressed in both the intestine and liver and form heterodimers that normally function to …

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ATP-Binding Cassette Transporter G5 and G8 …

2012-5-24 · Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001; 69:278–290. [PMC free article]

SOME REMARK OSN CADREM LONCHOPTEROIDEA S …

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(PDF) Introducing high-throughput sequencing into ...

PDF | Inherited platelet disorders are a heterogeneous group of rare diseases, caused by inherited defects in platelet production and/or function. Their... | …

(PDF) Sterolins ABCG5 and ABCG8: regulators of whole …

ABCG5 and ABCG8 are two ATP-binding cassette half-transporters that belong to the G family members. They were identified as proteins that are mutated in a rare human disorder, sitosterolemia, and their identification led to the completion of the

ATP-binding cassette G5/G8 deficiency causes ...

2011-12-1 · No significant differences in weight were found among mice of different genotypes, although it tended to be lower in G5/G8−/− mice ().Plasma total sterol levels in fasted animals were 1.5 and 1.6-fold significantly higher in G5/G8−/− mice than in G5/G8+/− and G5/G8+/+ mice, respectively ().G5/G8−/− and G5/G8+/− mice also showed several previously reported …